The Impact of Sleep on Endometriosis: How Sleep Affects Immune System, Hormones, and Inflammation

Paul Deschamps

A chronic illness that affects women's reproductive systems is endometriosis. Endometrium, the tissue that lines the uterus, can develop outside of the uterus and onto other pelvic organs like the ovaries, fallopian tubes, and intestines to cause the condition. Infertility, severe pain, and profuse menstrual bleeding are all side effects of endometriosis.

Sleep has been shown to have an effect on endometriosis. Sleep and endometriosis are strongly correlated, according to research. This article will examine the relationship between sleep and endometriosis, including how it impacts inflammation, hormone levels, and the immune system.

Sleep and the immune system 

The growth and progression of endometriosis are significantly influenced by the immune system. Endometrial tissue that is proliferating outside the uterus is one example of a foreign substance or cell that the immune system is capable of identifying and attacking. Lack of sleep can impair the immune system's ability to function properly, making it more challenging for the body to fight off the growth of endometrial tissue, according to research.

According to a study in the journal Sleep Medicine Reviews, pro-inflammatory cytokines can rise as a result of sleep deprivation. Immune cells release proteins called pro-inflammatory cytokines in response to injury or infection. Elevated cytokine levels have been linked to the emergence and spread of endometriosis.

Sleep and hormones

Additionally, hormones are very important in endometriosis. A complex interplay of hormones, including progesterone and estrogen, controls the menstrual cycle. Sleep issues have been linked in studies to altered hormone levels, which can result in the onset and progression of endometriosis.

Compared to women without endometriosis, women with endometriosis had lower levels of the hormone melatonin, which controls sleep, according to a study in the Journal of Women's Health. The study also discovered that follicle-stimulating hormone (FSH), a hormone that affects the menstrual cycle, was present in higher amounts in endometriosis-affected women.

 Sleep and Inflammation 

Endometriosis is characterized by inflammation. Endometrial tissue outside of the uterus can result in persistent inflammation, which brings on pain and discomfort. Sleep can affect inflammation levels, which can make endometriosis symptoms worse, according to research.

According to a study in the Journal of Clinical Sleep Medicine, women who slept for fewer than six hours each night had higher levels of the inflammatory marker C-reactive protein (CRP) than those who slept for seven to nine hours each night. The study also discovered that endometriosis symptoms, such as pain and fatigue, were more severe in women who slept for fewer than six hours every night.


Endometriosis develops and spreads in large part as a result of sleep. Lack of sleep can impair the immune system's capacity to fight infection, mess with hormone levels, and increase inflammation, all of which can hasten the onset and progression of endometriosis, according to research. Women who have endometriosis must prioritize sleep and make sure they get enough rest each night.


  • Burney, R. O., & Giudice, L. C. (2012). Pathogenesis and pathophysiology of endometriosis. Fertility and Sterility, 98(3), 511–519.

  • Fung, J. N. T., & Julius, A. (2019). The influence of sleep on the immune function of the female reproductive tract. Sleep Medicine Reviews, 44, 72–79

November 1, 2023

New Patients

Get Started

Current Patients

Log in
Join our newsletter
Thank you! Your submission has been received!
Oops! Something went wrong while submitting the form.
Disclaimer: Moona Health offers telehealth services focusing on the self-management and well-being of individuals diagnosed with insomnia. It is designed to complement, not replace, the care provided by your healthcare provider or existing insomnia treatments. Continue following your healthcare provider's guidance, including medication regimens. If you experience thoughts of self-harm or harming others, immediately contact emergency services by dialing 911 (or your local emergency number) or visit the nearest emergency department.
© Copyright 2024 Moona Health